BREAST CANCER

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Tumor Sampling

+Pathologic Findings of Follow-up Surgical Excision for Lobular Neoplasia on Breast Core Biopsy Performed for Calcification

Pathologic Findings of Follow-up Surgical Excision for Lobular Neoplasia on Breast Core Biopsy Performed for Calcification

Chengquan Zhao, MD et al.

This article examines the pathologic findings of surgical follow-up excision on patients who had radiologic finding of calcifications and lobular neoplasia on core biopsy.
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+The Effects of Under 6 Hours of Formalin Fixation on Hormone Receptor and HER2 Expression in Invasive Breast Cancer

The Effects of Under 6 Hours of Formalin Fixation on Hormone Receptor and HER2 Expression in Invasive Breast Cancer

Shona Kalkman, MD et al.

This article reviews pre-analytic literature to identify whether minimum formalin fixation time may be reduced for reliable ER/PR and HER2 IHC determination.
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+Diagnostic Use of Immunohistochemistry in Breast Pathology: Invasive Ductal vs. Invasive Lobular

Diagnostic Use of Immunohistochemistry in Breast Pathology: Invasive Ductal vs. Invasive Lobular

Rohit Bhargava, M.D.

This short course will explain the differences between invasive ductal vs. invasive lobular. It will also explain when to use E-cadherin for tumors with ambiguous morphology.
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+Diagnostic Use of Immunohistochemistry in Breast Pathology: Assessment of Invasion

Diagnostic Use of Immunohistochemistry in Breast Pathology: Assessment of Invasion

Rohit Bhargava, M.D.

Course Description: This mini course will diagnose invasive carcinoma prior to a definitive excision procedure, describe how immunohistochemical (IHC) stains supplement the morphologic diagnosis, and list the markers available for the assessment of invasion.
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+Diagnostic Use of Immunohistochemistry in Breast Pathology: Lymphatic Space Invasion

Diagnostic Use of Immunohistochemistry in Breast Pathology: Lymphatic Space Invasion

Rohit Bhargava, M.D.

This course will explain the use of D2-40 as a selective lymphatic endothelial marker and how it can be helpful in identifying lymphatic space invasion and identifying lymphatic tumor emboli in cases of inflammatory carcinoma.
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+Diagnostic Use of Immunohistochemistry in Breast Pathology: Paget’s Disease

Diagnostic Use of Immunohistochemistry in Breast Pathology: Paget’s Disease

Rohit Bhargava, M.D.

This short course will describe Paget’s disease, distinguish between Paget’s disease from Bowen’s disease and melanoma, use positive CK7 and Her2 stains to positively identify Paget’s disease, describe helpful negative stains and less helpful positive stains for Paget’s disease identification and explain the IHC profile of breast cancer.
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+Diagnostic Use of Immunohistochemistry in Breast Pathology: Spindle Cell Lesions

Diagnostic Use of Immunohistochemistry in Breast Pathology: Spindle Cell Lesions

Rohit Bhargava, M.D.

This mini course will discuss how metaplstic carcinomas are heterogenerous and describe how to diagnose problematic cases which show predominant spindle cell morphology.
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+Diagnostic Use of Immunohistochemistry in Breast Pathology: Papillary Lesions

Diagnostic Use of Immunohistochemistry in Breast Pathology: Papillary Lesions

Rohit Bhargava, M.D.

This course will discuss papillary lesions which include: intraductal papilloma, papilloma with ADH, papilloma with DCIS, papillary DCIS, encapsulated (intracystic/encysted) papillary carcinoma, solid papillary carcinoma and invasive papillary carcinoma.
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+Diagnostic Use of Immunohistochemistry in Breast Pathology: IHC to Diagnose ADH

Diagnostic Use of Immunohistochemistry in Breast Pathology: IHC to Diagnose ADH

Rohit Bhargava, M.D.

This short course will go over the diagnosis of ADH using CK5, ADH and ER.
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+Variable specimen handling affects hormone receptor test results in women with breast cancer: a large multihospital retrospective study. Arch Pathol Lab Med 134:606-12, 2010

Variable specimen handling affects hormone receptor test results in women with breast cancer: a large multihospital retrospective study. Arch Pathol Lab Med 134:606-12, 2010

Nkoy FL, Hammond ME, Rees W, et al

This aricle focuses on a study conducted from women who had breast cancer surgery the variability of ER/PR negativity throughout hospitals and how specimen handling is related to their results.
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+Breast Cancer Predictive Factor Testing: The Challenges and Importance of Standardizing Tissue Handling

Breast Cancer Predictive Factor Testing: The Challenges and Importance of Standardizing Tissue Handling

David G. Hicks, LeeAnn Kushner, Kristin McCarthy

This article discusses the current standards for collection and preservation of clinical samples that have been in place for decades and have focused on tissue preservation for morphologic examination, with little if any attention paid to preserving the quality of macromolecules that may be in the tissue. Because of the importance of these markers for determining the most appropriate treatments available for each patient, there is a need for standardizing pre-analytic variables, with the goal of developing standardized methods of tissue procurement and processing, and documenting how these variables affect the quality of tissue for biomarker testing and molecular analysis.
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+The effect of cold ischemic time on the immunohistochemical evaluation of estrogen receptor, progesterone receptor, and HER2 expression in invasive breast carcinoma. Mod Pathol. 2012 Aug;25(8):1098-105. doi: 10.1038/modpathol.2012.59. Epub 2012 Mar 30. PubMed PMID: 22460807.

The effect of cold ischemic time on the immunohistochemical evaluation of estrogen receptor, progesterone receptor, and HER2 expression in invasive breast carcinoma. Mod Pathol. 2012 Aug;25(8):1098-105. doi: 10.1038/modpathol.2012.59. Epub 2012 Mar 30. PubMed PMID: 22460807.

Yildiz-Aktas IZ, Dabbs DJ, Bhargava R. l

Breast resection specimens were subjected to variable cold ischemic time periods (0.5, 1, 2, 3, 4, 24, and 48 h) within the refrigerator and at room temperature. The study included 25 tumors, all of which had refrigerated samples. Non-refrigerated samples (samples at room temperature) were present on 23 cases. Hormone receptors were semi-quantitatively scored using the H-score method. Human epidermal growth factor receptor 2 gene ERBB2 (HER2) was scored using the ASCO/CAP guidelines. The results were compared with the core biopsy scores, which have negligible cold ischemic time period before fixation.
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